ANRS 0515s EBO-PEP

Evaluation of the efficacy of a post-exposure prophylaxis (PEP) strategy in contacts at high risk of developing Ebola virus disease

Last updated on 17 December 2025

Main points

EBO-PEP is a multi-country and multi-epidemic trial in which high risk contact (children, adolescents, adults) of contracting
Ebola virus disease are recruited during an epidemic in several countries

  • Democratic Republic of Congo,
  • Guinea,
  • Liberia,
  • Sierra Leone.

Objectives of EBO-PEP

Multicenter, multi-epidemic, phase III, comparative, controlled, randomized, one-sided, superiority trial with two parallel, unblinded
arms.

Main objective

  • Compare the rate of EVD at 21 days in contacts at high-risk of EVD receiving a PEP strategy of ERV+IMZ vs. ERV alone.

Secondary objectives

  • Compare the rate of EVD at 60 days in contact at high-risk of EVD receiving a PEP strategy with ERV+IMZ versus ERV alone
  • Compare safety and tolerance between the different trial arms
  • Compare EVD severity between the different trial arms
  • Compare the rate of asymptomatic EVD between the different trial arms
  • Compare the proportion of deaths between the different trial arms
  • Describe the evolution of viral load in the different trial arms
  • Estimate the cost-effectiveness ratio in the different trial arms
More on EBO-PEP

Criteria

Inclusion criteria

  • Last high-risk contact within the last 5 days
  • No sign or symptoms of EVD
  • Signed and dated informed consent from participants over the age of majority in order to participate in the trial or from a representative of parental authority for minor participants

Primary endpoint

  • Proportion of participants with EBOV PCR-confirmed symptomatic EVD between D1 and D21.

Coordinating Investigators:
Pr Placide Mbala & Dr Marie Jaspard

Structure/teams
ALIMA, MEREVA, INRB, CERFIG, ANSS, ISGlobal, UCAD, PANTHER, NPHIL, NPHA, INSP, Inserm

Status
To be start

Pathology
Ebola virus disease (EVD)

Sponsorship
ANRS MIE / Inserm

Funding
EDCTP3

Download the study information for researchers

.pdf 308 KB

Download the study information for participants

.pdf 176 KB

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