Activity Report 2025

Highlights of ANRS MIE’s work in 2025

The agency continued to strengthen its European and international engagement, notably through its coordination of major research partnerships and its active participation in the European research landscape. It also reinforced its partnership with the World Health Organization (WHO), which designated ANRS MIE as the coordinating centre for the Filovirus Collaborative Open Research Consortium (CORC), making the agency a WHO Collaborating Centre. Our 2025 Scientific Days, dedicated to “The challenges of international research”, underscored the urgent need to foster international scientific cooperation to address the global health challenges we face.

This year also saw major advances in our historical areas of expertise. The prospect of an HIV cure—once considered beyond reach—has never seemed closer. Yet these achievements should not overshadow a fundamental reality: HIV, viral hepatitis and tuberculosis continue to affect millions of people worldwide and require sustained scientific commitment. Finally, our Outbreak Response programme once again demonstrated its value by enabling a rapid and proportionate research response to outbreaks of filovirus diseases, chikungunya, West Nile fever and Rift Valley fever. It has become an essential mechanism for strengthening preparedness and responding to future epidemic threats.

At a glance: 2025 Activity Report

This Activity Report is structured around four main sections:

• Preparedness for epidemic crises

This pillar is based on the consolidation and strengthening of research infrastructures at both national (OPEN-ReMIE, I-REIVAC, EMERGEN 2.0) and international levels (PROACT EU-Response, STRIVE network, GloPID-R, BE READY). In a context of increasing infectious disease threats, 2025 marked an important step in reinforcing preparedness and response capacities for health crises. ANRS MIE continued to pursue a strategy focused on reducing the time needed to mobilise research, strengthening research infrastructures at national and international levels, and structuring global partnership.

• Response to emerging threats: research mobilised in real time

In France, as in Europe and internationally, ANRS MIE plays a very particular role in the scientific landscape for the response to epidemic crises: it acts as a leading player, inter-institutional pilot and research accelerator. It has established a coordination and monitoring procedure to respond rapidly to health crises through its Outbreak Response programme. In 2025, this mobilisation capacity was put into practice on several occasions in response to infectious threats such as the Ebola and Marburg viruses, Rift Valley fever, arboviruses and viral respiratory infections, confirming the agency’s role in structuring and coordinating scientific responses in epidemic periods.

• Supporting research: project highlights in 2025

The research conducted and supported in 2025 illustrates the continuity of the agency’s main scientific priorities and its ability to foster new research dynamics. These include advances in HIV prevention and remission strategies, improved care for tuberculosis and viral hepatitis, the development of projects focused on emerging infectious diseases, and the deployment of large-scale structural programmes aimed at sustainably strengthening research and innovation capacities.

• Facilitating the scientific community

In 2025, ANRS MIE’s strategy resulted in the deployment of new scientific coordination mechanisms, the organisation of structuring scientific events and the strengthening of its International Network. The agency paid particular attention to supporting the new generation of researchers through specific funding mechanisms and networking actions (Start programme).