Enhances Europe’s capacity to provide a rapid response to the mpox international outbreak
Last updated on 23 June 2024
MPX-RESPONSE aims to increase the knowledge of mpox, to evaluate potential treatments, and to strengthen Europe’s global preparedness for emerging infectious disease outbreaks.
In 2022, the multi-country outbreak of mpox (Monkeypox) virus disease was declared a public health emergency of international concern by the World Health Organization (WHO). One year later, in 2023, the end of the emergency was announced but ongoing reported cases are under surveillance as the threat of new outbreaks remains real. In addition, people continue to be infected with mpox virus in previously affected countries, and an unprecedented mpox epidemic is currently ravaging the Democratic Republic of Congo (DRC) and affecting a broader population.
A better understanding of the disease will allow effective strategies for patient management and treatment, preventing a global health crisis.
This project involves 16 leading international scientifc partners:
In response to the 2022 outbreak of mpox disease, the World Health Organization (WHO) has promoted a structured and coordinated approach to prevent redundant research efforts and expedite the assessment of treatments against mpox disease. A group of experts, convened by the WHO and ANRS MIE, has been tasked with developing a core protocol, designed to promote global collaboration. Trials seeking to support this collaborative exchange are encouraged to adopt standardized inclusion criteria and endpoints. The UNITY, MOSA and EPOXI protocols were developed based on the WHO core protocol. While inclusion criteria are adapted to the local context, all three studies share the same primary endpoint, enabling possibility to pool data and promptly reach more robust conclusions.
The protocols of all three trials are based on the WHO CORE protocol, designed for a global trial assessing drug safety and efficacy in treating human mpox (tecovirimat), with the goal of securing marketing authorization from the EMA, if the treatment demonstrates positive results.
The objective of this observational study is to deepen our understanding of the clinical and virological outcomes in patients diagnosed with mpox. This approach aims to provide a comprehensive insight into the natural history of the disease. This cohort, in addition to European Union countries, is conducted in United Kingdom and Switzerland. Oxford University is the sponsor of the study and ANRS MIE the sponsor representative in European Union.
Through MPX-RESPONSE, our goal is to increase the knowledge on mpox and to evaluate treatments to better fight against the disease in Europe and globally, thanks to the unique international dimension of the consortium. A methodology designed to promote collaboration harmonises inclusion criteria and primary endpoint across the three clinical trials in MPX-RESPONSE, enabling data pooling and ultimately allowing to reach more robust conclusions in a timely manner.
MPX-RESPONSE is organized into 4 Work Packages (WP)