ANRS 176 RHIVIERA-02

A randomised phase II placebo-controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo during primary HIV-1 infection to study the impact on post-treatment HIV control.

Published on 20 March 2024

Primary objective

Evaluate if the administration of a treatment consisting of dual long-acting HIV-specific broadly neutralizing antibodies (3BNC117-LS & 10-1074-LS (bNAbs)), in combination with an antiretroviral therapy (ART) in individuals with primary HIV-1 infection (PI) when compared to ART only (with neutralizing antibodies or placebo) will favour a period of HIV-1 remission when ART is interrupted 52 or 76 weeks later.

Theme
HIV-1

Population
Adult

Status
Ongoing

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